Acetic Anhydride → HCID 19804741, compound

HRID 1709344Notes

Reaction equation

HRID 1709344 reaction equation
[Cl:1][C:2]1[C:10]([CH2:11][OH:12])=[C:9]([S:13]([CH3:16])(=[O:15])=[O:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[C:17]([O:12][CH2:11][C:10]1[C:2]([Cl:1])=[C:3]([CH:7]=[CH:8][C:9]=1[S:13]([CH3:16])(=[O:15])=[O:14])[C:4]([OH:6])=[O:5])(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 151328832-Chloro-3-(hydroxymethyl)-4-methylsulfonylbenzoic acid

Product 1

HCID 19804741HCID 19804741, compound

Procedure

1.3 g of 2-chloro-3-hydroxymethyl-4-methanesulfonyl benzoic acid and 30 ml of acetic anhydride, was refluxed for 3 hours under heating. The reaction mixture was concentrated under reduced pressure. Then, 50 ml of water was added thereto and warmed for 1 hour. Precipitated solid was collected by filtration, washed with water and dried to obtain 1.35 g of the desired product. Melting point: 219°-223° C.

Workup

  1. temperatureunder heating
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. additionThen, 50 ml of water was added
  4. temperaturewarmed for 1 hour
  5. customPrecipitated solid
  6. filtrationwas collected by filtration
  7. washwashed with water
  8. customdried

Sources & evidence

ORD record
ord-4870feb49671420f95dc54fb5a9934c2
Source dataset
uspto-grants-1990_08
Patent number
US04948887

Reaction notes

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