3-Nitrobenzaldehyde → HCID 15078614, compound

Participants

Reaction Steps

A solution of 2.04 g of 2-acetylthioethyl acetoacetate, 1.51 g of 3-nitrobenzaldehyde, 1.49 g of methoxyethyl 3-aminocrotonate and 0.15 g of piperidinium acetate in 20 ml of 2-propanol was refluxed for 4 hours. After evaporation of the solvent under reduced pressure, the residue was purified by silica gel column chromatography [eluent: ethyl acetate - hexane (1 : 3)]to give 1.54 g of the title compound. m.p. 136-138° C.

Provenance & Evidence