Trifluoroacetic acid → HCID 140345175, compound

Participants

Reaction Steps

550 mg of rac-cis-3-[(Z)-2-(2-amino-4-thiazolyl)-2-[[1-(t-butoxycarbonyl)-1-methylethoxy]imino]acetamido]-4-methoxycarbonyl-2-oxo-1-azetidinesulphonic acid are added at room temperature to 5.5 ml of trifluoroacetic acid. After 45 minutes, the mixture is evaporated and the residue is purified by chromatography on reverse-phase silica gel using water/methanol (4:1). There are obtained 27 mg of pure rac-cis-3-[(Z)-2-(2-amino-4-thiazolyl)-2-[(1-carboxy-1-methylethoxy)imino]acetamido]-4-methoxycarbonyl-2-oxo-1-azetidinesulphonic acid as an amorphous lyophilizate.

Provenance & Evidence