Trifluoroacetic acid → HCID 131715083, compound

Participants

Reaction Conditions

Reaction Steps

1.755 g (4.38 mmol) of rac-cis-3-(1-t-butoxyformamido)-4-[(Z)-2-(ethoxycarbonyl)-1-methylvinyl]-2-oxo-1-azetidinesulphonic acid sodium salt are dissolved in 7.5 ml of anisole and the solution is treated at -20° C. with 10 ml of trifluoroacetic acid. After stirring at -20° C. for 30 minutes and then at room temperature for a further 3 hours, the solution is diluted with 300 ml of ether/n-hexane (1:1). The crystals obtained are filtered off, dissolved in 10 ml of water and chromatographed on MCI gel. 808 mg (60%) of rac-cis-3-amino-4-[(Z)-2-(ethoxycarbonyl)-1-methylvinyl]-2-oxo-1-azetidinesulphonic acid are obtained.

Provenance & Evidence