反应详情

温度

22.5 °C

2,4,6-Trichloropyridine (1800 g, 9.89 mol) was dissolved in ethanol (1800 mL). Methylamine 40% solution in ethanol (6.3 L) was added over 1 h and 40 min maintaining the reaction temperature between 20-25° C. The reaction was stirred for 14 hours at room temperature and concentrated. The product was filtered, washed with methyl t-butyl ether (1,500 ml) and dried to yield A1.6 (1200 g, 68%)

1. concentrationconcentrated
2. filtrationThe product was filtered
3. washwashed with methyl t-butyl ether (1,500 ml)
4. customdried
5. customto yield A1.6 (1200 g, 68%)