Potassium Hydroxide → 6-Nitro-2,5-pyridinediamine

HRID 1709611Notes

Reaction equation

HRID 1709611 reaction equation
C(OC([NH:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(OCC)=O)=[C:9]([N+:19]([O-:21])=[O:20])[N:8]=1)=O)C.[OH-].[K+]>>[NH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH2:13])=[C:9]([N+:19]([O-:21])=[O:20])[N:8]=1

Participants

3

Reactant 2

HCID 14797Potassium HydroxideHCID 14366181HCID 14366181, compound

Product 1

HCID 98152436-Nitro-2,5-pyridinediamine

Procedure

4.0 g of the biscarbamate of Example 9 are boiled in 200 ml of an ethanolic 3 percent potassium hydroxide solution for 18 hours with reflux. This is followed by filtering and the filtrate is acidified with concentrated sulphuric acid, whereupon it is concentrated in vacuo. The residue is taken up in methanol. The desired product then crystallizes as hydrochloride (melting point 241° C.).

Workup

  1. temperaturewith reflux
  2. filtrationby filtering
  3. concentrationis concentrated in vacuo
  4. customThe desired product then crystallizes as hydrochloride (melting point 241° C.)

Sources & evidence

ORD record
ord-4764633e04894bfd9aa008fa8af608f2
Source dataset
uspto-grants-1990_08
Patent number
US04950302

Reaction notes

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