Benzene → HCID 53964454, compound

Participants

Reaction Steps

A suspension of 17.8 grams (0.1 mole) of β-benzoyl-propionic acid (Organic Synthesis, 2:81) in 500 milliters of dry benzene is prepared and 10.5 grams of triethylamine, 15 grams of ethyl chloroformate, and 18 grams (0.2 mole) of morpholine are sequentially added. The suspension is stirred for two hours at room temperature and then filtered to remove the precipitated triethylamine hydrochloride. The mother liquor is evaporated in a small amount for filtration and the solid product which is obtained, is separated by filtration and crystallized from ethanol to provide about 15 grams of N-morpholinyl-β-benzoyl-propionamide having a melting point of 87°-89° C.

Provenance & Evidence