HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → HCID 53964454, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 3-Benzoylpropionic acid | HCID 72871 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53964454 | HCID 53964454 | 74.3% |
Reaction Steps
A solution is prepared containing 17.8 grams (0.1 mole) β-benzoyl-propionic acid in 500 ml of anhydrous tetrahydrofuran. There are then added 20.7 grams (0.1 mole) dicyclohexylcarbodiimide and 9.8 grams (0.2 mole) morpholine. The reactants are reacted at reflux for 30 hrs. The reaction mixture is allowed to cool. The cooled mixture is filtered and the filtrate is concentrated to about one-fifth its initial volume. After vacuum drying, there are obtained 19.5 grams of crystalline N-morpholinyl-β-benzoyl-propionamide having a melting point of 88°-89° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04950669 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-2c275ef874e94a8ea1e8bbbe4911a65b |
| Source note | uspto-grants-1990_08 |