反应详情

Capryloyl chloride (0.602 mol; 98 g) was dropwise added during 1.5 hour into a mixture of ethylene glycol (3 mol; 186 g) and pyridine (0.6 mol; 47.4 g). The mixture was further stirred for 2 hours at laboratory temperature, allowed to stand overnight, and threetimes extracted with benzene (100+50+25 ml). The benzene extract was shaken with a 10% aqueous solution of NaHCO3 (2×30 ml) and water and benzene was evaporated in a rotation evaporator. Distillation of the residue gave 4 raw fractions with purity 79.9 to 97.9% at the overall yield of 2-hydroxyethyl caprylate 79.5%. Further procedure was carried out according to example 1.

1. waitto stand overnight
2. extractionthreetimes extracted with benzene (100+50+25 ml)
3. extractionThe benzene extract
4. stirringwas shaken with a 10% aqueous solution of NaHCO3 (2×30 ml) and water and benzene
5. customwas evaporated in a rotation evaporator
6. distillationDistillation of the residue