Methyl iodide → HCID 14126773, compound

HRID 1709727Notes

Reaction equation

HRID 1709727 reaction equation
ClC1[C:11]2[N:10]=[CH:9][CH:8]=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1.[CH3:12][I:13].[C:14](#N)C>>[I-:13].[I:13][CH:12]1[C:11]2[N+:10]([CH3:14])=[CH:9][CH:8]=[CH:7][C:6]=2[CH2:5][CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 6328Methyl iodideHCID 6342AcetonitrileHCID 137121808-Chloro-5,6,7,8-tetrahydroquinoline

Product 1

HCID 14126773HCID 14126773, compound

Procedure

A solution of 13.70 g of 5,6,7,8-tetrahydro-8-chloroquinoline (preparation given below), 86 ml of acetonitrile and 15.2 ml of methyl iodide was stirred for 68 hours at ambient temperature and crystallization was started after 50 minutes of reaction. The crystals were separated, rinsed with acetonitrile, then with ether and dried under reduced pressure at 20° C. to obtain 29.96 g of 8-iodo-1-methyl-5,6,7,8-tetrahydro-1-quinolinium iodide melting at 175° C.

Workup

  1. customcrystallization
  2. customwas started after 50 minutes of reaction
  3. customThe crystals were separated
  4. washrinsed with acetonitrile
  5. dry with materialwith ether and dried under reduced pressure at 20° C.

Sources & evidence

ORD record
ord-96c44997ed75494a81cbd8bf4ed779c7
Source dataset
uspto-grants-1990_08
Patent number
US04950760

Reaction notes

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