Acetic Acid → 3-Acetylpyridine

Participants

Reaction Steps

A mixture of 29 g/h of methyl nicotinate, 76 g/h of acetic acid and 26 g/h of water was evaporated in an evaporator and passed, together with 10 l/h of nitrogen, at 420° C., over 150 ml of a catalyst which contained 2% by weight of sodium oxide, the remainder being anatase. The reaction gases were then cooled and were collected in a receiver. From the discharged two-phase mixture, the organic phase was analyzed by gas chromatography. The conversion of nicotinic ester and of acetic acid was 100% in each case. The selectivity with respect to 3-acetylpyridine was 54%. In addition, pyridine was formed with a selectivity of 41%.

Provenance & Evidence