反应详情

A solution of 9.4 g of 2-(chloromethyl)-3-methyl-4-nitropyridine and 10 g of 5-(trifluoromethyl)-2-benzimidazolethiol in 260 ml of abs. acetone was treated with 3 g of finely ground potassium carbonate and stirred at room temperature under argon for 18 hours. 180 ml of acetone were distilled off in a vacuum, whereupon the remaining portion of the reaction mixture was poured on to ice. The crystallized-out product was filtered off and dried at 35° in a drying oven By recrystallization from ethyl acetate/n-hexane there was obtained 2-[[(3-methyl-4-nitro 2-pyridyl)methyl]thio]-5-(trifluoromethyl)benzimidazole of melting point 192°-193°.

1. distillation180 ml of acetone were distilled off in a vacuum, whereupon the remaining portion of the reaction mixture
2. additionwas poured on to ice
3. filtrationThe crystallized-out product was filtered off
4. dry with materialdried at 35° in a drying oven By recrystallization from ethyl acetate/n-hexane there