Water → 4-chloro-N-hexadecyl-N-methyl-3-nitrobenzenesulfonamide

Participants

Reaction Steps

170 g of N-hexadecyl-3-nitro-4-chlorobenzenesulfonamide was dissolved in 640 ml of acetone, and 79 g of potassium carbonate, 6 ml of polyethylene glycol (average molecular weight: 400), and 71 g of dimethyl sulfate were added thereto, followed by refluxing the mixture for 5 hours under heating. 240 ml of acetone was added to the reaction solution, and 870 ml of water was further dropwise added thereto with stirring and keeping the temperature of the reaction solution at 40° C. Cooling the mixture to room temperature yielded crystals. The crystals were collected by filtration, washed in succession with water and methanol and then dried.

Provenance & Evidence