Water → 4-chloro-N-hexadecyl-N-methyl-3-nitrobenzenesulfonamide

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Reaction Steps

170 g of N-hexadecyl-3-nitro-4-chlorobenzenesulfonamide was dissolved in 640 ml of acetone, and 79 g of potassium carbonate, 4006 ml polyethylene glycol, and 71 g of dimethyl sulfate were added thereto, followed by refluxing the mixture for 5 hours under heating. Then, 240 ml of acetone was added thereto, and 870 ml of water was dropwise added thereto at 40° C. Upon cooling the mixture to room temperature, crystals were precipitated. The crystals were collected by filtration, washed with water and methanol successively, and then dried.

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