Water → 3-(8-Quinolinyloxy)-1-propanol

HRID 1709838Notes

Reaction equation

HRID 1709838 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.CC(C)([O-])C.[K+].Cl[CH2:19][CH2:20][CH2:21][OH:22].O>CS(C)=O>[N:10]1[C:11]2[C:6](=[CH:5][CH:4]=[CH:3][C:2]=2[O:1][CH2:19][CH2:20][CH2:21][OH:22])[CH:7]=[CH:8][CH:9]=1

Participants

6

Reactant 4

HCID 962WaterHCID 19238-HydroxyquinolineHCID 123133-Chloro-1-propanolHCID 23665647Potassium tert-butoxide

Product 1

HCID 132957843-(8-Quinolinyloxy)-1-propanol

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Conditions

Temperature
70 °C

Procedure

A solution of 8-hydroxyquinoline (36.0 g, 0.25 mole) and potassium tertbutoxide (28.0 g, 0.25 mole) in 80 ml of dimethyl sulfoxide was stirred for 1 hr at room temperature. 3-Chloro-1-propanol (242.0 g, 0.25 mole) was added and the solution was heated overnight at 70° C. The solution was poured into 500 ml of water. A brown solid/mass was obtained. The solid was washed with several portions of water and then triturated with acetone. The solid was filtered and dried in vacuo at 80° C. overnight to give 35.67 g (70.3%) of light brown solid, m.p. 126°-127° C.

Workup

  1. customA brown solid/mass was obtained
  2. washThe solid was washed with several portions of water
  3. customtriturated with acetone
  4. filtrationThe solid was filtered
  5. customdried in vacuo at 80° C. overnight
  6. customto give 35.67 g (70.3%) of light brown solid, m.p. 126°-127° C.

Sources & evidence

ORD record
ord-59923ab1c0c240eb8ae5018c5e295906
Source dataset
uspto-grants-1990_08
Patent number
US04950674

Reaction notes

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