HCID 23036274, compound → HCID 23036262, compound

Participants

Reaction Steps

A solution of 26.6 g (0.07 mole) of α,α-bis(4-fluorophenyl)-1-(phenylmethyl)-3-pyrrolidinemethanol in 500 ml of ethanol was hydrogenated at 60 psi and 70° C. over 5% palladium on carbon catalyst for 2 days. The mixture was cooled and filtered through Celite®. The filtrate was concentrated under reduced pressure to give a solid as residue. The solid was triturated with petroleum ether (30°-60° C.), collected by filtration and dried to yield 18.5 g (91%) of the title compound as a white solid, m.p. 152°-153° C. (2-propanol).

Provenance & Evidence