Benzenesulfonyl chloride → HCID 23036364, compound

Participants

Reaction Steps

A solution of 15.18 g (0.0529 mole) of 4-[bis(4-flurophenyl)methylene]piperidine and 10,89 g (0.0617 mole) of benzenesulfonyl chloride in 350 ml of pyridine was stirred at room temperature for 16 hr. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and dilute sulfuric acid. The methylene chloride solution was extracted with dilute sodium hydroxide, and the methylene chloride solution was dried over sodium sulfate. The solvent was removed in vacuo, and the residue was dissolved in 200 ml of methanol. A precipitate was collected. This was recrystallized from methylene chloride - methanol to give 11.14 g (49.3%) of the title compound as a white solid: mp 180-184° C.

Provenance & Evidence