Benzene, (3-bromopropoxy)- → HCID 23036406, compound

Participants

Reaction Steps

A mixture of 3.37 g (0.011 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.52 g (0.011 mole) of (3-bromopropoxy)benzene and sodium bicarbonate (3.7 g, 0.035 mole) in 200 ml of 1-butanol was heated overnight at reflux. The butanol was removed by the rotary evaporator, and the residue partitioned between chloroform and water. Removal of the chloroform in vacuo gave a dark brown oil, the free base of the title compound. The base was converted to the oxalate salt and recrystallized from methanol-ethyl ether to give 1.41 (23.9%) of white solid, m.p. 163° C.

Provenance & Evidence