HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[3-(4-Chlorophenoxy)propyl]-alpha,alpha-bis(4-fluorophenyl)-4-piperidinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | HCID 12685610 | HCID 12685610 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 1-[3-(4-Chlorophenoxy)propyl]-alpha,alpha-bis(4-fluorophenyl)-4-piperidinemethanol | HCID 14407084 | — |
Reaction Steps
A mixture of 3.0 g (0.01 mole) of [α,α-bis(p-fluorophenyl)]4-piperidinemethanol, 2.0 g (0.01 mole) of 1-chloro-4-(3-chloropropoxy)benzene, 5.3 g (0.05 mole) of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 ml of 1-butanol was heated at reflux for 20 hr to give, after working up as in Example 1 (recrystallizing the free base from isopropyl alcohol), 1.7 g (36%) of white solid, m.p. 92°-93° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04950674 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-52f29875c41249a0975bd2e69259d96e |
| Source note | uspto-grants-1990_08 |