HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bis(4-fluorophenyl)(piperidin-4-yl)methanol → 1-[3-[4-(1,1-Dimethylethyl)phenoxy]propyl]-alpha,alpha-bis(4-fluorophenyl)-4-piperidinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 1-tert-Butyl-4-(3-chloropropoxy)benzene | HCID 12928625 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-[3-[4-(1,1-Dimethylethyl)phenoxy]propyl]-alpha,alpha-bis(4-fluorophenyl)-4-piperidinemethanol | HCID 14407110 | 41% |
Reaction Steps
Following the procedure of Example 1, α,α-bis (p-fluorophenyl)-4-piperidinemethanol and 4-(3-chloropropoxy)-(1,1-dimethylethyl)benzene were reacted using potassium iodide catalyst to give with white powder (recrystallizing from isopropyl alcohol) in 41% yield, m.p. 126°-127° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04950674 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-9f2f695d445a4c198f337d5b86034b09 |
| Source note | uspto-grants-1990_08 |