HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 14407122, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 1-[4-(2-Chloroethoxy)-3-methoxyphenyl]ethanone | HCID 14407170 | — |
| Catalyst | Potassium Iodide | HCID 4875 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | HCID 14407122 | HCID 14407122 | 22% |
Reaction Steps
Following the procedure of Example 1 and utilizing potassium iodide catalyst, a mixture of 3.0 g (0.01 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.3 g (0.01 mole) of 1-[4-(2-chloroethoxy)-3-methoxyphenyl]-ethanone and sodium carbonate in butanol, the title compound was prepared in 22% yield, m.p. 131°-135° C., after recrystallization from isopropyl alcohol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04950674 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-b67fb05cde7040928764f4e196736fe4 |
| Source note | uspto-grants-1990_08 |