1-Butanol → HCID 23036370, compound

Participants

Reaction Steps

A mixture of 6.10 g (0.021 mole) of 4-[bis(4-fluorophenyl)methyl]piperidine and 4.53 g (0.021 mole of 4-(3-chloropropoxy)benzamide in 350 ml of 1-butanol containing potassium carbonate (5.53 g, 0.021 mole) and potassium iodide (0.2 g) was heated overnight at gentle reflux. The reaction was filtered and stripped to dryness. The residue obtained was dissolved in chloroform and extracted with water. The chloroform layer was dried, filtered, and solvent removed to give an oil. This material was converted to the fumarate salt and recrystallized from methanol-ethyl ether. The white, crystalline solid obtained was dried in vacuo overnight at 65° C. A yield of 5.47 g (40.3%) of white, crystalline product was obtained, m.p. 193°-194° C.

Provenance & Evidence