Bis(4-fluorophenyl)(piperidin-4-yl)methanol → HCID 44271552, compound

HRID 1709890Notes

Reaction equation

HRID 1709890 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[OH:9])=[CH:4][CH:3]=1.[CH2:23]([O:25][C:26](=[O:39])[NH:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][CH2:37]Br)=[CH:30][CH:29]=1)[CH3:24]>>[CH2:23]([O:25][C:26](=[O:39])[NH:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][CH2:35][CH2:36][CH2:37][N:13]2[CH2:12][CH2:11][CH:10]([C:8]([C:16]3[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=3)([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[OH:9])[CH2:15][CH2:14]2)=[CH:30][CH:29]=1)[CH3:24]

Participants

3

Reactant 2

HCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 54291441HCID 54291441, compound

Product 1

HCID 44271552HCID 44271552, compound

Procedure

Following the procedure of Example 1, [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol and [4-(3-bromopropoxy)phenyl]carbamic acid ethyl ester are reacted to give the title compound.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-4e63d059973f486bbd0c1292106bb759
Source dataset
uspto-grants-1990_08
Patent number
US04950674

Reaction notes

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