HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → alpha,alpha-Bis(4-fluorophenyl)-1-[3-(4-methoxyphenoxy)propyl]-4-piperidine-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 1-(3-Chloropropoxy)-4-methoxybenzene | HCID 12685612 | — |
| Reactant | 4-(Diphenylmethylene)-1-(3-phenoxypropyl)piperidine oxalate | HCID 23036335 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | alpha,alpha-Bis(4-fluorophenyl)-1-[3-(4-methoxyphenoxy)propyl]-4-piperidine-methanol | HCID 23036341 | 49.2% |
Reaction Steps
This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.0 g (0.01 mole) of α,α-bis (p-fluorophenyl)-4-piperidinemethanol, 2.0 g (0.01 mole) of 1-chloro-3-(4-methoxyphenoxy) propane, 5.3 g (0.035 mole) of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 ml of 1-butanol gave 2.3 g (49% yield) of title compound as a white solid, mp 107°-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04950674 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-76242115c2f341d28a733cb1be6e0f1d |
| Source note | uspto-grants-1990_08 |