HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[3-(4-Ethyl-2-methoxyphenoxy)propyl]-alpha,alpha-bis (4-fluorophenyl)-4-piperidinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-(4-Ethyl-2-methoxyphenoxy)propyl chloride | HCID 10398913 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 4-(Diphenylmethylene)-1-(3-phenoxypropyl)piperidine oxalate | HCID 23036335 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 1-[3-(4-Ethyl-2-methoxyphenoxy)propyl]-alpha,alpha-bis (4-fluorophenyl)-4-piperidinemethanol | HCID 23036302 | 74.7% |
Reaction Steps
This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.0 g (0.01 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.3 g (0.01 mole) of 3-(4-ethyl-2-methoxyphenoxy)propyl chloride, 5.3 g (0.05 mole) of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 ml of 1-butanol gave 3.7 g (74%) of title compound as a white solid, mp 118°-120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04950674 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-b23a47c542cd4c04967b61185daa79a6 |
| Source note | uspto-grants-1990_08 |