Potassium Iodide → 3-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-benzoic acid ethyl ester fumarate

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Reaction Steps

This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.0 g (0.01 mole) of α, α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.4 g (0.01 mole) of 3-(3-chloropropoxy)benzoic acid ethyl ester, 3.7 g (0.035 mole) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 ml of dimethylformamide gave a gum as residue. The gum was converted to the fumaric acid salt and the solid was recrystallized from acetonitrile to yield 4.2 g (67%) of title compound as a fluffy,, white solid, mp 123°-131° C.

Provenance & Evidence