HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 1-[3-([1,1'-Biphenyl]-4-yloxy)propyl]-alpha,alpha-bis(4-fluorophenyl)-4-piperidinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | HCID 11118365 | HCID 11118365 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 4-(Diphenylmethylene)-1-(3-phenoxypropyl)piperidine oxalate | HCID 23036335 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 1-[3-([1,1'-Biphenyl]-4-yloxy)propyl]-alpha,alpha-bis(4-fluorophenyl)-4-piperidinemethanol | HCID 23036282 | 69% |
Reaction Steps
This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.0 g (0.01 mole) of α, α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.5 g (0.01 mole) of 4-(3-chloropropoxy)-1,1'-biphenyl, 3.7 g (0.035 mole) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 ml of 1-butanol gave 3.5 g (69%) of title compound as a white solid, mp 108°-109° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04950674 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-2379e84eeea14b0589a08f0f520f6d5a |
| Source note | uspto-grants-1990_08 |