HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanol → 1-[4-[3-[4-[Bis(4-fluorophenyl)-hydroxymethyl]piperidin-1-yl]propoxy]phenyl]propan-1-one;propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanol | HCID 263 | — |
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 1-[4-(3-Chloropropoxy)phenyl]-1-propanone | HCID 12399685 | — |
| Reactant | 4-(Diphenylmethylene)-1-(3-phenoxypropyl)piperidine oxalate | HCID 23036335 | — |
| Product | 1-[4-[3-[4-[Bis(4-fluorophenyl)-hydroxymethyl]piperidin-1-yl]propoxy]phenyl]propan-1-one;propan-2-ol | HCID 86744174 | 76% |
Reaction Steps
This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.0 g (0.01 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.3 g (0.01 mole) of 1-[4-(3-chloropropoxy)phenyl]-1-propanone, 3.7 g (0.035 mole) of anhydrous sodium carbonate and 0.4 g of potassium iodide in 100 mol of 1-butanol gave 3.7 g (76%) of title compound as a white solid, mp 57°-62° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04950674 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-91230ec421d84c8e9fe810aa0ed632bd |
| Source note | uspto-grants-1990_08 |