Potassium Iodide → HCID 23036407, compound

Participants

Reaction Steps

This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.0 g (0.01 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 2.8 g (0.01 mole) of 1-[4-(4-chlorohexyloxy)-3-methoxyphenyl]ethanone, 5.3 g (0.05 mole) of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 ml of 1-butanol gave a gum as resiude. The gum was purified by column chromatography on 80 g of Florisil®. Fractions eluted with 2-5% acetone in benzene were combined and concentrated to give a glass as residue. The glass was dissolved in anhydrous ethyl ether, filtered and the filtrate treated with ethereal hydrogen chloride. A gummy solid precipitated. This solid was triturated with fresh ethyl ether until a fine, white solid resulted. The solid was collected by filtration and dried to yield 1.0 g (17%) of title compound as a white solid, mp 182°-186° C. with decomposition.

Provenance & Evidence