Potassium Iodide → HCID 86744176, compound

Participants

Reaction Steps

This compound was prepared according to the procedure used to synthesize the compound of Example 1. A mixture of 3.7 g (0.012 mole) of the base of [α,α-bis(4-fluoropheny]-3-piperidineethanol hydrochloride [1:1], 2.8 g free (0.012 mole) of 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone, 4.3 g (0.04 mole) of anhydrous sodium carbonate and 0.5 g of potassium iodide in 100 ml of 1-butanol gave a gum as residue. The gum was purified by column chromatography on 120 g of Florisil®. Fractions eluted with 20-60% acetone in benzene were combined and concentrated to give a gum. This gum was converted to the fumaric acid salt and the solid was recrystallized from ethyl acetate-acetonitrile to yield 2.6 g (35%) of the title compound as a white solid, mp 133°-136° C.

Provenance & Evidence