HCID 131716517, compound → HCID 131716516, compound

Participants

Reaction Steps

Boc-Phe-Gly-Leu-Gln-AMC was prepared by coupling Boc-Phe-Gly-Leu-OH (0.39 g, 0.90 mmol) to H-Gln-AMC trifluoroacetate (0.41 g, 0.99 mmol) by a mixed anhydride coupling procedure to yield 0.49 g crude product. Product was recrystallized from ethyl acetate to provide 0.27 g of Boc-Phe-Gly-Leu-Gln-AMC, mp 234°-236° with decomposition. TLC with methanol:chloroform (1:9) showed a single spot, Rf 0.20.

Provenance & Evidence