Trifluoroacetic acid → HCID 131716519, compound

Participants

Reaction Steps

Boc-Phe-Gly-Leu-Gln-AMC (0.63 g) was deblocked by treatment with trifluoroacetic acid at about 23°. Toluene was added to the resulting reaction mixture, and then the combined solvents were evaporated at reduced pressure , leaving a residue. This residue was redissolved in toluene, and the solvent was then evaporated again to leave a residue, which was dried in vacuo overnight over solid potassium hydroxide to provide 0.69 g of white, solid H-Phe-Gly-Leu-Gln-AMC trifluoroacetate. TLC with 1-butanol:acetic acid: water (4:1:1) showed two spots, Rf 0.58 and Rf 0.51.

Provenance & Evidence