Hydrochloric Acid → HCID 131716521, compound

Participants

Reaction Steps

Boc-Phe-Gly-Leu-Gln-NA was prepared by coupling Boc-Phe-Gly-Leu-OH (1.42 g, 3.25 mmol) to H-Gln-NA HCl (1.00 g, 3.25 mmol) by a mixed anhydride coupling procedure. A total of 10 mL DMF was used to dissolve H-Gln-NA HCl. During workup of the organic phase resulting from the mixed anhydride coupling procedure, some product crystallized and was separated, washed with water, and dried to yield 0.91 g of Boc-Phe-Gly-Leu-Gln-NA, mp 238°-239°. The remaining organic phase was washed with a saturated salt solution, and a second crop of crystalline product (0.62 g) was obtained, mp 238°-239°. A sample of the first crop was analyzed.

Provenance & Evidence