Glycine → HCID 178512907, compound

HRID 1709966Notes

Reaction equation

HRID 1709966 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=O)[CH2:3][C:4]([OH:6])=[O:5].[NH2:10][CH2:11][C:12]([OH:14])=[O:13].[NH2:15][C@H:16]([C:24]([OH:26])=O)[CH2:17][CH2:18][CH2:19][NH:20][C:21](=[NH:23])[NH2:22]>>[NH2:15][C@H:16]([C:24]([NH:1][CH2:2][C:7]([NH:1][C@H:2]([C:7]([NH:10][CH2:11][C:12]([OH:14])=[O:13])=[O:9])[CH2:3][C:4](=[O:5])[OH:6])=[O:9])=[O:26])[CH2:17][CH2:18][CH2:19][NH:20][C:21](=[NH:23])[NH2:22]

Participants

4

Reactant 3

HCID 750GlycineHCID 5960L-Aspartic AcidHCID 178418600HCID 178418600, compound

Product 1

HCID 178512907HCID 178512907, compound

Procedure

Starting with N-FMOC-glycine-p-alkoxy benzyl resin ester, sequentially coupling L-aspartic acid, glycine and arginine, deprotecting and removing the peptide as in the above examples, L-arginylglycyl-L-aspartyl glycine was obtained as the ditrifluoroacetate salt; m.p. 85°-90° C.

Workup

  1. customremoving the peptide as in the above examples

Sources & evidence

ORD record
ord-a70a009c3ecb4de49fae486238b09eec
Source dataset
uspto-grants-1990_08
Patent number
US04952562

Reaction notes

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