Ethyl bromoacetate → HCID 131716523, compound

HRID 1709985Notes

Reaction equation

[OH:1][C:2]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[CH:14][C:3]=1[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)=[O:5].Br[CH2:25][C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[CH2:29]([O:28][C:26]([CH2:25][O:1][C:2]1[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]([F:23])([F:21])[F:22])=[CH:14][C:3]=1[C:4]([NH:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)=[O:5])=[O:27])[CH3:30]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 15055922HCID 15055922, compound

Product 1

HCID 131716523HCID 131716523, compound

Procedure

Using the general method of Example I Part A, 9.8 g (0.03 mole) of 2-hydroxy-N-(2-pyridylmethyl)-5-(2,2,2-trifluoroethoxy)benzamide was reacted with 7.0 g (0.042 mole) of ethyl bromoacetate to give 7.6 g of ivory powdery -(ethoxycarbonylmethoxy)-N-(2-pyridylmethyl)-5-(2,2,2-trifluoroethoxy)benzamide, m.p. 109°-111° C.

Sources & evidence

ORD record: ord-8f5faeaddc7b48db8e3372b1ac7a43b2
Source dataset: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04952574

Reaction notes

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