2-Pyridinemethanamine → HCID 23035275, compound

HRID 1709995Notes

Reaction equation

[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:9][C:5]=1[C:6]([OH:8])=O)[CH3:2].[NH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1>>[CH2:1]([O:3][C:4]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]([F:18])([F:17])[F:16])=[CH:9][C:5]=1[C:6]([NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)=[O:8])[CH3:2]

Participants

Reactant 2

HCID 195092-Pyridinemethanamine

HCID 23035309HCID 23035309, compound

Product 1

HCID 23035275HCID 23035275, compound

Procedure

Using the general method of Example XXIII Part D, 15.4 g (0.058 mole) of 2-ethoxy-5-(2,2,2-trifluoroethoxy)benzoic acid was converted to the acid chloride and then reacted with 2-aminomethylpyridine to provide 14.1 g of crystalline 2-ethoxy-5-(2,2,2-trifluoroethoxy)-N-(2-pyridylmethyl)benzamide, m.p. 110°-111° C. Analysis: Calculated for C17H17F3N2O3 : %C, 57.6; %H, 4.85; %N, 7.9; Found: %C, 57.1; %H, 4.8; %N, 7.8.

Sources & evidence

ORD record: ord-61179c9afa9a49f991ed99c5a3244758
Source dataset: uspto-grants-1990_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04952574

Reaction notes

Loading…