HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzohydrazide → 2-(4-Chlorophenyl)-1,3,4-oxadiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzohydrazide | HCID 10816 | — |
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Product | 2-(4-Chlorophenyl)-1,3,4-oxadiazole | HCID 11600777 | — |
Reaction Steps
A stirred solution of 8.1 grams (0.048 mole) of 4-chlorobenzoic acid hydrazide in 300 ml of triethyl orthoformate was heated under reflux for 16 hours. The excess triethyl orthoformate was removed by distillation and the residual solid was stirred with petroleum ether to yield 7.7 grams of 2-(4-chlorophenyl)-1,3,4-oxadiazole; m.p. 129° C. The nmr spectrum was consistent with the proposed structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952580 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-d0b91243f74d48b094771a53d8a24f30 |
| Source note | uspto-grants-1990_08 |