HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-amino-1-(4-methoxybenzyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile → 4-Amino-9-(4-methoxyphenyl)methyl-2-methyl-5,6,7,8-tetrahydro-9H-pyrido[2,3-b]indole-3-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-amino-1-(4-methoxybenzyl)-4,5,6,7-tetrahydro-1H-indole-3-carbonitrile | HCID 2764069 | — |
| Reactant | Ethyl 3-ethoxy-2-butenoate | HCID 5904488 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-Amino-9-(4-methoxyphenyl)methyl-2-methyl-5,6,7,8-tetrahydro-9H-pyrido[2,3-b]indole-3-carboxylic acid, ethyl ester | HCID 86744179 | 64% |
Reaction Steps
The title compound was prepared in 64% yield from 2-amino-3-cyano-1-(4-methoxyphenyl)methyl-4,5,6,7-tetrahydroindole (D5) and ethyl β-ethoxycrotonate in a procedure similar to Description 6. Product was obtained as beige crystals from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952584 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-fc2eccfcfca74c62a66ff209bddf6882 |
| Source note | uspto-grants-1990_08 |