HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → 4-Amino-9-(4-methoxyphenyl)methyl-2-methyl-9H-pyrido[2,3-b]indole-3-carboxylic acid, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone | HCID 6775 | — |
| Reactant | 4-Amino-9-(4-methoxyphenyl)methyl-2-methyl-5,6,7,8-tetrahydro-9H-pyrido[2,3-b]indole-3-carboxylic acid, ethyl ester | HCID 86744179 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-Amino-9-(4-methoxyphenyl)methyl-2-methyl-9H-pyrido[2,3-b]indole-3-carboxylic acid, ethyl ester | HCID 86744180 | 73% |
Reaction Steps
The title compound was prepared in 73% yield from 4-amino-9-(4-methoxyphenyl)methyl-2-methyl-5,6,7,8-tetrahydro-9H-pyrido[2,3-b]indole-3-carboxylic acid, ethyl ester (D8) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone in a procedure similar to Description 7, using benzene as solvent instead of toluene. Product was obtained as white crystals from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952584 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-0a4180e9915844eab76da7e547b9a5db |
| Source note | uspto-grants-1990_08 |