HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromothiazole → HCID 14022497, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Reactant | 3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine | HCID 10220561 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 14022497 | HCID 14022497 | — |
Reaction Steps
3-[3-(Piperidinomethyl)phenoxy]propylamine (7.45 g) and 2-bromothiazole (2.46 g) in pyridine (25 ml) were stirred under reflux for 20 hours. The reaction mixture was cooled, evaporated and partitioned between chloroform and water. The chloroform layer was evaporated and subjected to medium pressure column chromatography on silica (chloroform:methanol 19:1) to give the title compound as an oil. This was converted to 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]thiazole dihydrochloride, m.p. 192.5°-193.5° C. (recrystallised from isopropanol-ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952589 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-ca83755c830b4af299e6ddd314fea7d4 |
| Source note | uspto-grants-1990_08 |