HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-methyl-2-(methylsulfanyl)-1H-1,3-benzodiazole → HCID 23035476, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-methyl-2-(methylsulfanyl)-1H-1,3-benzodiazole | HCID 415665 | — |
| Reactant | 3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine | HCID 10220561 | — |
| Product | HCID 23035476 | HCID 23035476 | — |
Reaction Steps
3-[3-(Piperidinomethyl)phenoxy]propylamine (2.41 g) and 1-methyl-2-methylthiobenzimidazole (1.57 g) were fused at 150° C. for 6 hours. The cooled residue was subjected to column chromatography on silica (chloroform:methanol 19:1) to give the title compound as an oil. This was treated with maleic acid to give 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]-1-methylbenzimidazole dimaleate (0.87 g), m.p. 153°-4° C. (recrystallised from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952589 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-f40e8b87f2fa41b3a51d36d43ac01357 |
| Source note | uspto-grants-1990_08 |