2-Chlorobenzothiazole → HCID 23035482, compound

Participants

Reaction Steps

5-(3-(Piperidinomethyl)phenoxy]pentylamine (0.8 g) and 2-chlorobenzthiazole (0.53 g) were fused at 140° C. for 3 hours. The cooled residue was subjected to medium pressure column chromatography on silica using ethyl acetate as eluant to give the title compound as an oil. This was converted to 2-[5-[3-piperidinomethyl)phenoxy]pentylamino]benzthiazole dihydrochloride (0.18 g), m.p. 140°-145° C. (recrystallised from ethanol/ether).

Provenance & Evidence