HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → HCID 10315285, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | 2-Chlorobenzothiazole | HCID 11987 | — |
| Reactant | 3-(3-Aminopropoxy)-N,N-dimethylbenzenemethanamine | HCID 12913950 | — |
| Solvent | Chloroform methanol | HCID 21584188 | — |
| Product | HCID 10315285 | HCID 10315285 | — |
Reaction Steps
3-[3-(Dimethylaminomethyl)phenoxy]propylamine (2.38 g) and 2-chlorobenzthiazole (1.94 g) were fused at 130° C. for 2 hours. The cooled residue was subjected to column chromatography on silica using chloroform followed by chloroform:methanol (25:1) as eluants to give the title compound as a yellow oil. This was converted to 2-[3-[3(dimethylaminomethyl)phenoxy]propylamino]benzthiazole dihydrochloride (0.37 g), m.p. 154°-155° C. (recrystallised from ethanol/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952589 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-3185900d0a0242a9973cbbad6e7c7109 |
| Source note | uspto-grants-1990_08 |