HCID 14439311, compound → 2,4-Difluoro-5-(trifluoromethoxy)aniline

Participants

Reaction Steps

In a hydrogenation apparatus, 27 g of 3-nitro-4,6-difluoro-trifluoromethoxy-benzene in 150 ml of tetrahydrofuran are hydrogenated at 30 to 50 bar hydrogen at 25° to 45° C., in the presence of 3 g of Raney nickel. When the hydrogen uptake is complete, the mixture is filtered, and the filtrate is distilled. 19 g of 3-amino-4,6-difluoro-trifluoromethoxy-benzene of a boiling point of 82° to 83° C. at 20 mbar are obtained.

Provenance & Evidence