Ammonia → 4-Amino-2,3-difluorobenzotrifluoride

HRID 1710110노트

반응식

HRID 1710110 반응식
[F:1][C:2]1[C:7]([F:8])=[C:6](F)[CH:5]=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11].[NH3:14]>O1CCCC1>[F:1][C:2]1[C:7]([F:8])=[C:6]([NH2:14])[CH:5]=[CH:4][C:3]=1[C:10]([F:13])([F:12])[F:11]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 27340251,2,3-Trifluoro-4-(trifluoromethyl)benzene

생성물 1

HCID 27359024-Amino-2,3-difluorobenzotrifluoride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
130 °C

실험 절차

200 g of 2,3,4-trifluorobenzotrifluoride in 500 ml of tetrahydrofuran are introduced in an autoclave, and 60 ml of liquid ammonia are forced in. The mixture is stirred at 130° C. for 6 hours (maximum pressure 18 bar), cooled, and released. By distillation, 72 g of 2-amino-3,4-difluoro-benzotrifluoride are obtained at a boiling point of 60° to 64° C. at 26 mbar and 92 g of 2,3-difluoro-4-amino-benzotrifluoride are obtained at a boiling point of 92° to 93° C. at 26 mbar.

후처리

  1. temperaturecooled
  2. distillationBy distillation, 72 g of 2-amino-3,4-difluoro-benzotrifluoride

출처 및 근거

ORD 기록
ord-1e9af3e2279f4919b2b874168e573793
출처 데이터셋
uspto-grants-1990_08
특허 번호
US04952601

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