Benzyl Bromide → HCID 13772341, compound

Participants

Reaction Steps

20.24 g (0.08 mol) of 1-methyl-3-(2-methoxyphenyl)indolin-2-one are dissolved in 200 ml of dry THF. Then 9.2 g (0.08 mol) of potassium tertiary-butylate are added, and the mixture is stirred at room temperature for 15 minutes. At 10°, a solution of 12.1 ml of benzyl bromide in 20 ml of dry THF is added dropwise, and the mixture is then stirred at room temperature for 3 hours. It is then concentrated in vacuo, the residue is partitioned between water and ethyl acetate, and the organic phase is washed twice with water, dried and concentrated. 26.1 g of product of melting point 174°-176° C. are obtained.

Provenance & Evidence