Boron tribromide → HCID 13772343, compound

Participants

Reaction Steps

25 g (0.073 mol) of 3-benzyl-1-methyl-3-(2-methoxyphenyl)indolin-2-one are dissolved in 250 ml of methylene chloride. The solution is cooled to 0°-5° and a solution of 7 ml (0.074 mol) of boron tribromide in 50 ml of methylene chloride is added dropwise over the course of 30 minutes, and the mixture is then stirred at room temperature for 1 hour and poured onto ice-water. The organic phase is separated off, washed twice with water, dried over magnesium sulfate and concentrated. 17.8 g of crystalline product of melting point 188°-190° C. are obtained.

Provenance & Evidence