Potassium Iodide → HCID 13365560, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3 5 g (0.01 mol) of 1-cyclopropyl-6,8-difluoro-7-(piperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid, 2.1 g of triethylamine, 1.8 g of cyclopropylmethyl chloride and 3.3 g of potassium iodide is heated to 80° C. for 6 hours. Thereafter, the mixture is evaporated down in vacuo, 30 ml of water are added, the mixture is adjusted to pH 5 and the precipitate is filtered off under suction, washed with water and methanol and recrystallised from glycol monomethyl ether. 1.8 g of 1-cyclopropyl-7-(4-cyclopropylmethylpiperazin-1-yl)-6,8-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid having a decomposition temperature of 246°-248° C. are obtained.

Provenance & Evidence