HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → HCID 14031969, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Ethyl 1-(3-chlorophenyl)-1H-imidazole-4-carboxylate | HCID 14031968 | — |
| Catalyst | Titanium isopropoxide | HCID 11026 | — |
| Product | HCID 14031969 | HCID 14031969 | 63% |
Reaction Steps
A solution of 0.4 g of 1-(3-chlorophenyl)-imidazole-4-carboxylic acid ethyl ester in 40 ml of i-propanol is mixed with 0.5 ml of titanium tetraisopropanolate and refluxed for 8 hours. After concentration of the solution, it is filtered over silica gel and recrystallized from diisopropyl ether. 267 mg (63%) of the title compound with a melting point of 109° C. is obtained from diisopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04952698 |
| Source dataset | uspto-grants-1990_08 |
| ORD ID | ord-4783586d96ce448cb657d53232001012 |
| Source note | uspto-grants-1990_08 |