HCID 86744189, compound → Pirazolac

HRID 1710200Notes

Reaction equation

HRID 1710200 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([CH2:20][C:21]([O-:23])=[O:22])=[N:9]2)=[CH:4][CH:3]=1>[Pd]>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]2[CH:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:10]([CH2:20][C:21]([OH:23])=[O:22])=[N:9]2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 86744189HCID 86744189, compound

Product 1

HCID 51222Pirazolac

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1,49 Grams (3 mM) of the benzohydryl [1-(4-fluorophenyl)-4-(4-chlorophenyl)-1H-pyrazol-3-yl]-acetate are dissolved in 40 ml of tetrahydroflurane. To the solution 0,4 g of Pd on charcoal (10%) are added, then the mixture is hydrogenated at room temperature and pressure. At the end of the reaction the catalysator is filtered, the solvent evaporated and the product crystallized from acetic acid/ethanol. The title product is obtained in almost quantitative yield.

Workup

  1. customis hydrogenated at room temperature
  2. customAt the end of the reaction the catalysator
  3. filtrationis filtered
  4. customthe solvent evaporated
  5. customthe product crystallized from acetic acid/ethanol

Sources & evidence

ORD record
ord-f2ab52f269b44a928d2852f75c3558b9
Source dataset
uspto-grants-1990_08
Patent number
US04952702

Reaction notes

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